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Prof. Jianghua Chen's Group Published a Paper to Reveal the Effect of Angiotensin-Converting En

2015-11-11   |  

Diabetes mellitus (DM) is increasing in prevalsence world- wide and afflicts an estimated 6.6% of the global adult population, or approximately 285 million individuals. By 2030, an estimated 350 million people worldwide will be living with DM. Mortality rates from CV disease in patients with DMare2-to4-fold higher compared with those in patients without DM。The renin-angiotensin-aldosterone system is a major regulatory system of CV and renal function. Thus, multiple clinical trials in past decades have confirmed that suppression of renin-angiotensin-aldosterone system activity might be expected to reduce CV mortality and all-cause mortality. Despite the above findings, however, the cardioprotective effects of renin-angiotensin-aldosterone system blockade were recently called into question. In light of the above, the research team led by Prof. Jianghua Chen undertook the present meta-analysis aiming to overcome this limitation by evalsuating the effect of ACEIs and ARBs separately vs placebo or other medications on the incidence of all-cause mortality, CV deaths, and CV events in patients with DM.