Professor Chao He and his group firstly compared the secretome of fresh cultured CRC tumor tissues and paired normal colorectal (NC) tissues under near physiological conditions. They applied a lectin affinity based approach to enrich secreted proteins in the conditioned media of cultured tissues. The captured proteins were analyzed by the proteomic strategy of one-dimensional gel electrophoresis coupled to liquid chromatography−tandem mass spectrometry. They found 123 expressed secreted proteins (DESPs) between the CRC tissues and NC tissues. Compared with previous studies on functional genomics and proteomics, EFEMP2 was identified as a promising novel serum biomarker for CRC early detection by further research. The study was published in the Journal of Proteome Research.
Over recent decades, A. baumannii has emerged as a major global hospital-acquired pathogen. Bloodstream infections (BSIs) caused by this bacterium carry a mortality rate of up to 60% and imp...
SAHZU Neurologist Prof. LOU Min and her team recently found that, despite an increased risk of symptomatic intracranial hemorrhage, intravenous alteplase provided functional benefit to acute ischemic ...
The genome, made up of DNA, contains not only protein-coding sequences but also a vast array of non-coding regulatory sequences. These two types of sequence work in concert to shape the complex phenot...
