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Gu Y, Zheng W,  HYPERLINK "https://www.ncbi.nlm.nih.gov/pubmed/?term=Zhang%20J%5BAuthor%5D&cauthor=true&cauthor_uid=27012864" Zhang J,  HYPERLINK "https://www.ncbi.nlm.nih.gov/pubmed/?term=Gan%20X%5BAuthor%5D&cauthor=true&cauthor_uid=27012864" Gan X,  HYPERLINK "https://www.ncbi.nlm.nih.gov/pubmed/?term=Ma%20X%5BAuthor%5D&cauthor=true&cauthor_uid=27012864" Ma X, Meng Z, Chen T,  HYPERLINK "https://www.ncbi.nlm.nih.gov/pubmed/?term=Lu%20X%5BAuthor%5D&cauthor=true&cauthor_uid=27012864" Lu X,  HYPERLINK "https://www.ncbi.nlm.nih.gov/pubmed/?term=Wu%20Z%5BAuthor%5D&cauthor=true&cauthor_uid=27012864" Wu Z, Huang W, Xu R. Aberrant activation of CaMKII accelerates chronic myeloid leukemia blast crisis. Leukemia. 2016; 30(6):1282-1289 2. Chen T, Meng Z, Gan Y, et al. The viral oncogene Np9 acts as a critical molecular switch for co-activating -catenin, ERK, Akt and Notch1 and promoting the growth of human leukemia stem/progenitor cells. Leukemia. 2013; 27(7):1469-1478 3. Gu Y, Chen T, Meng Z, et al. CaMKII  "          ( * , : < > B D F R T X Z \ b d h j l | ~ 箸坌判判判罕ū煥睙ū煥报睙ūū煥槺ū彣报睙ūū煥报睙 h5aJo(h'9h5aJ h'9hT2h'9h:aJh'9hT2aJh'9h2caJh'9hT2CJaJh'9hyRCJaJh'9h2cCJaJh'9h2c5丆JaJh'9hT25丆JaJh'9h2c5丆JaJ5"    * < 刬$IfWD2`刬gd:$If$a$ < > kd$$If杔4攢执jS _]!€€€€€€€n€ t0!    44 lalf4yt5> D L T Z d j v ~ 勔$IfWDd`勔gd: $Ifgd:刬刬$IfVD2WD2^刬`刬gd:刬剹$IfWD^刬`剹gd:$If     " @ B D F J L P R Z ^ ` j l ~   , 4 6 黝遛斟钐逭逭逭钫逭迤款遛斟跺斟斟斟钫钫钫钫钫钫钫钫遛斟h'9hraJh'9haJh'9h>(!aJh'9h XaJ h5aJo( h5aJh'9hS?aJh'9h2caJ h'9hT2h'9hT2aJh'9h:aJh'9h5aJ= kd$$If杔4攢执jS _]!€€€€€€€n€ t0!    44 lalf4yt5  刬$IfWD2`刬gd5 $IfgdS?$If  " B 2,# $Ifgd X$Ifkd$$If杔4攢謭_]!€€ €€€n€ t0!44 lalf4yt5B F L R  Ckd$$If杔4旫謀_!€€ €€h t0!44 lalf4yt5剉$IfWD,`剉gd:$If R T ruo[M dH$G$Ifgd弞}劋dH$G$IfWD`劋gdUW($Ifkd$$If杔4斘0!€€ t0!44 lalf4yt5 $Ifgdr6 R T V    0 黟甾仗煤锰饱櫏寵櫏檪x檟檕fo橺h'9h5>*aJh'9h˙aJh'9haJh'9h>*aJh'9hS?5乤Jh5hS?56>*aJh'9h5>*aJh'9hS?5>*aJh'9hS?aJh'9h鶻aJh'9h縏BaJh'9hT aJh'9h *[aJh'9hT2aJh'9h2caJ h'9hT2h'9h>(!aJvzpL46PR.<P\^b黝孱巯巯明搴骱饱睘饱饱敟敟眾饱饱饱眱饱znzh'9h瑍5>*aJh'9h瑍aJ h/-aJo(h'9h弞}6乤Jh55>*aJo( h'9hT2h'9h弞}5>*aJh'9h弞}aJh'9hw aJh'9hp]5>*aJh'9h5>*aJh'9h>*aJh'9haJh'9haJh'9hp]aJ*JL~xxxfNB dH$Ifgd鵢g劉dH$G$IfWDYD2`劉gd闗OdH$G$IfXD2gd弞}$IfkdD$$If杔4攓#0!€€ t0!44 lalf4yt5tu|}€cdhirsy{|jz88849@9h:::;.;:;<=N=絷翎葬葬葬葬葬葬葬葬葬牯嵩嵩嵩嵩嵩嵩崛岱翎柔翎滇柔翎柔翎翎珶h'9h"T5>*aJh5h鵢g6乤JU h'9h鵢g5丅*PJaJphh'9h鵢g56乤Jjh'9h鵢gUaJh'9h鵢gaJh'9h鵢g5乤Jh'9h鵢g5>*aJ<9:;=N=> \ dH$@&IfYD2gd. dH$Ifgd鵢g \ dH$@&Ifgd鵢g, a critical regulator of CML stem/progenitor cells, is a target of the natural product berbamine. Blood. 2012; 120(24):4829-4839. 4. Xu X, Gan Y, Xu G, Chen T, et al. Tetrandrine citrate eliminates imatinib-resistant chronic myeloid leukemia cells in vitro and in vivo by inhibiting Bcr-Abl/-catenin axis. J Zhejiang Univ-Sci B. 2012; 13(11):867-874 MANUSCRIPTS IN PREPARATION FOR SUBMISSION 1. Shao Y, Chen T , Zheng X, et al.  Colorectal Cancer-derived Small Extracellular Vesicles Create an Inflammatory Pre-metastatic Niche Through Macrophage Polarization in Liver Metastasis research article in preparation for submission to Cancer Research MANUSCRIPTS IN PREPARATION 1. Chen T, Xu Y, Yu Q, et al.  Np9 Protein of Human Endogenous Retrovirus K Induces Genome Instability through Interaction with -catenin in Human Leukemia research article in preparation蹚頞t1u0RRek緥骮蔛剺g顅h颯鍿D杣 N0蹚頞t1u 1. 4ng觔絒齎E柶壩 f[`Nv^R恎齎ENAm縺$vf[褃剉xvz`魚 2. 飝乬鸞Bl齎ET\O :N裇榗bb杽vuirD崘n漑揯鸞~b烻R'`剉亃4x筫T 孨0RRek緥骮蔛剺g顅h 1. ,g篘eQL€錘eg(W烻 g@埐m縺$vxvz剉鶺@x N萐瀀燫哊Y抍蔞醠薔黐剉觺魐爛Lv潃l忹y:g6Rxvz v^諷梍哊N歔剉b済 0N蘙哊陙馷鵞縺$v剉茓蔛`€郪dk dk!k鶴齎繈顣 b骮(W軴c@埐m縺$v槝z)R蹚L垊v T鰁 觺Tb霳縺$vxvz@b剉xvzD崘n(W觺魐爛Lv剉l忹y:g6R N_U\蹚Nek"} 2. 飝乬N鵞筫槝#嵑N蹚L垽NAm 耂燫蟢N!k槝▼簨 f[`Nv^R恎鵞筫剉褃f[`魚0xvz筫TNdk T鰁 R恎陙馷xvz錧\O剉O縍N縍 鸞~b0RN*N蛻筽T\O襝eQ筽 蹚Nek裇%c孴>e'Yb霳騗 g剉O縍 汻b:N 縺$vhQof_xvz購R貧翑 -N臺 N颯\0齎E枂楬QNwQ g蛻亯aIN剉 簢N墧  3. 1u嶯Am鰁魰 gP 蛻筽緥孴_U\T(WNS踲'Yf[瀃寶蹚L垊v錧\O $\vQ/f≧ir!j媁剉鷁藌 :N'}@w剉b Ny橆v孴齎ET\Oy橆vSb N瀃寶鶺@x 4. s^鰁揵OO蟢*N!h匭F€,Tf[/gJT剉:gO 飝乬耂燫1-2!k坢SS悓T@埐mf[縺$v剉齎E杅[/gO畫 v^塏諷O畫JT剉:gO 5. Yu鶴钀R鰁魰躡繈MD Anderson Cancer Center0University of Pennsylvania0蔛 HYPERLINK "http://www.baidu.com/link?url=atXbCorc40yfVSn4MnoDNzf4kq94CPJtwy7L0cFRCTa&wd=&eqid=cf8f844c000084920000000459f023f0" \t "_blank" Rutgers Cancer Institute of New Jersey T婲蔛€^ f[`N諲霳剉g癳筫T蔛瀃寶HQ蹚剉t!j_ ^g齹:Nb@b剉裇U\N鷁緥衏汷漑5崉v蟸寶 N0轛齎T錧\OSb梴 轛齎T亯鐍韣N鶴繈USMO軴c芠R剉槝T\O秗` 裇%c齎匭剉瀃寶蔛D崘n O縍 塏諷齎匭颯錘T\O剉O4O 錘g_U\錘,gUSMO:N;N剉wQ g陙;N鍂茓Cg剉R癳y橆vxvz03u鲖篘 b鷭,g篘b鷭 N饛Ty-N@b衏汷剉臽礠w瀃鄀飲0 3u鲖篘~{W[@b(WUSMO╟Pa翂 Ta穬VY篘XT(W鶴齎僗 g魰玁譙,gUSMOlQ>m鶴齎鴙sQ卂G0 啒黐~{W[ 講鄗 t^ g 錯鶺褢t訷XTO╟Pa翂 ;N鸑~{W[ 講鄗 t^ g 錯     N=P=R=T=`==*>,>B>`>>>>>>???? ????????@@@8@j@碄禓篅粿継黝湄钕钕钕钊慷檺檺瑖~u~n~e~u~e~噽\h'9haJh'9h雋aJ h5aJo(h'9haJh'9h_aJh'9hIMaJh'9ha$aJh'9haJh'9h.]5乤Jh'9h:v5乤Jh'9hT2aJh'9h2caJ h'9h弞}h'9hP4*aJh'9h鵢g5>*aJh'9h鵢g5乤Jh'9h鵢gaJh'9h"TaJ$>>>?H???窣藺{occcWW dH$Ifgd~ dH$IfgdE~ dH$IfgdUW($If~kd$$If杔:60!€€ t0!44 lalyt.継華蔄藺˙珺闎霣 C CPCRClDnD篋糄EE0E2E|E~E訣諩蹺轊釫銭FFFF F0F2FjFnF玎坂坂粥肃肃肃暮哀灖棊厧厧厧厳|sh]h'9hT2CJaJh'9h2cCJaJh'9hT2aJh'9h2caJh'9hT2aJh'9h2caJ h'9hT2h'9h5aJh'9hIMaJh'9h55乤Jh'9h:v5乤J h'9hjh'9hIMU h-=bo( h5o( h'9hIMh'9ha$aJh'9haJ h'9h$藺ZB蜝E2E~E訣諩轊銭ZTT$Ifkd$$If杔4 *0!€€ t0!44 lalf4yt'9 dH$Ifgd_ dH$IfgdIM d$Ifgd~ 銭FF F2FlFnFzF|F侳睩蔉蜦ikd6$$If杔4擧0!€€ t0!44 lalf4ytIM刪$IfWD`刪gd趍p$If nFxF|F€F侳癋睩菷蔉蘁褾蹻郌銯鍲鬎鯢鶩麱GGGG GGGG黝黝黝黝黝黝黝黝邕圻圻圻坨h豿jh豿U h'9hT2h'9hT2aJh'9h2caJ蜦蠪褾轋郌鍲鯢鳩Ikd$$If杔擬謀w!€€ €€P  t0!44 lalyt5 刄$IfWD`刄$If鳩鶩﨔GGG G GGGGGgd T6gdE~ 6182P:pT2皞. 捌A!"#悹$悹%癝班 愋$$If杔!vh#v#v#v#v#v#v#vn#v:V 杔4攢 t0!,5555555n5/ alf4yt5$$If杔!vh#v#v#v#v#v#v#vn#v:V 杔4攢 t0!,5555555n5/ alf4yt5$$If杔!vh#v#v #v#v#vn#v:V 杔4攢 t0!,55 555n5/ alf4yt5$$If杔!vh#v#v #v#vh:V 杔4旫 t0!,55 55h/ alf4yt5$$If杔!vh#v#v:V 杔4斘 t0!,55/ alf4yt5$$If杔!vh#v#v:V 杔4攓# t0!,55/ alf4yt5$$If杔!vh#v#v:V 杔:6 t0!,55/ alyt.$$If杔!vh#v#v:V 杔4 * t0!,55/ alf4yt'9$$If杔!vh#v#v:V 杔4擧 t0!,55/ alf4ytIM$$If杔!vh#v#v #v#vP :V 杔擬 t0!,55 55P / alyt5z?慑蔏⑶細(*z?慑蔏⑶細(*z?慑蔏⑶細(*z?慑蔏⑶細(*b vvvvvvvvv<4><<hH66<666666666666666666666666666666666666666666666646666 0@P`p€6666 0@P`p€ 0@P`p€ 0@P`p€ 0@P`p€ 0@P`p€ 0@P`p€8XV~PJ_HmH nHsH tHJ`J T2ck噀 $1$a$ CJKH_HaJmH nHsH tH$A`$ 貫祂=刉[SOBi@B 0nf恏*B*ph2B2 T2 R鶴祂=1WD`勅`劋.Q. 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